Decapod crustacean specimens from the middle Eocene San Juan Formation in central Chiapas represent the first record of Eocene decapods in southern México. New taxa include: Dardanus mexicanus new species (Diogenidae), Lophoranina cristaspina new species, Notopus minutus new species (Raninidae); Verrucoides stenohedra new genus and new species (Xanthidae); Stoaplax nandachare new genus and new species (Goneplacidae); and Viapinnixa alvarezi new species (Pinnotheridae). Verrucoides verrucoides new genus and new combination from the Paleocene of Greenland represents a new combination. In addition, the fauna includes Callianassa sensu lato sp., Laeviranina sp., Calappilia cf. C. hondoensis Rathbun, 1930, Eriosachila sp., and indeterminate calappid and xanthoid taxa. This assemblage bears close relationship with coeval faunas in the Tethyan region of southern Europe and southern North America and with Paleocene faunas of Greenland, strengthening the evidence for previously described patterns of dispersal within the Decapoda.