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12 November 2020 Video Microscopic Analysis of Invasion of Toxoplasma gondii into Peritoneal Macrophages
Yu Jin, Saeed El-Ashram, Yong Yao, Jijia Shen, Xun Suo, Xianyong Liu, Yongsheng Ji
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Abstract

Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect all nucleated cells through active invasion. Some non-canonical pathways for T. gondii infection of macrophages have recently been reported. We report a new mode of T. gondii invasion using a time-lapse imaging system, in which T. gondii tachyzoites are engulfed by a tube-like structure on peritoneal macrophage phagosomes and then escape from the phagosomes. Escaped parasites re-invade macrophages through intercellular junctions between their apical end and host cell membranes. We call this invasion pathway of T. gondii “pseudopod-assisted invasion” (PAI). The completion of this invasion process depends on parasitic motility and secretion of adhesins from parasitic micronemes. Our results provide new information about T. gondii infection and establish another platform for studying interactions between T. gondii and macrophages.

© American Society of Parasitologists 2020
Yu Jin, Saeed El-Ashram, Yong Yao, Jijia Shen, Xun Suo, Xianyong Liu, and Yongsheng Ji "Video Microscopic Analysis of Invasion of Toxoplasma gondii into Peritoneal Macrophages," Journal of Parasitology 106(6), 715-720, (12 November 2020). https://doi.org/10.1645/19-152
Published: 12 November 2020
JOURNAL ARTICLE
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KEYWORDS
macrophage
Pseudopod-Assisted Invasion
Toxoplasma gondii
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