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1 April 2000 THE SESQUITERPENE LACTONE DEHYDROLEUCODINE (DhL) AFFECTS THE GROWTH OF CULTURED EPIMASTIGOTES OF TRYPANOSOMA CRUZI
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Abstract

Here,we report an inhibitory effect of a sesquiterpene lactone dehydroleucodine (DhL) on the growth of Trypanosoma cruzi in culture. At concentrations of the drug between 5 and 10 µg/ml in the medium,the parasites remained alive for at least 4 days. Higher concentrations of DhL were lethal for the parasites within a few hours. The effect of DhL is irreversible. Morphological changes induced by DhL were also observed in the parasites. The effect of DhL was blocked by the presence of reducing substrates such as glutathione or dithiothreitol, but these agents were not able to reverse the effect of DhL if added 2 days after the start of drug exposure.

Silvia D. Brengio, Silvia A. Belmonte, Eduardo Guerreiro, Oscar S. Giordano, Elisa O. Pietrobon, and Miguel A. Sosa "THE SESQUITERPENE LACTONE DEHYDROLEUCODINE (DhL) AFFECTS THE GROWTH OF CULTURED EPIMASTIGOTES OF TRYPANOSOMA CRUZI," Journal of Parasitology 86(2), 407-412, (1 April 2000). https://doi.org/10.1645/0022-3395(2000)086[0407:TSLDDA]2.0.CO;2
Received: 23 November 1998; Accepted: 1 August 1999; Published: 1 April 2000
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