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1 June 2000 Haemonchus contortus (Nematoda: Trichostrongylidae) Is Much More Sensitive than Caenorhabditis elegans (Nematoda: Rhabditidae) to the Ovicidal Action of Thiabendazole
Airaj Fasiuddin, William C. Campbell
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Abstract

When eggs of the trichostrongylid nematode Haemonchus contortus were exposed to thiabendazole, the concentration required to prevent hatching in 90% of the eggs (MIC90) was found to be 0.1 μg/ml (using 1% dimethylsulfoxide [DMSO] as solvent). In contrast, eggs of the free-living rhabditid nematode Caenorhabditis elegans hatched at normal rates at a concentration 200 times higher, i.e., 20 μg/ml, and showed only a partial inhibitory effect at a concentration 1,200 times higher, i.e., 120 μg/ml (in 3% DMSO). Because solubility limitations precluded the testing of higher concentrations of thiabendazole, a more soluble derivative, 5-([1-methylethoxy]carbonylamino)-2-(4-thiazloyl)-1H-benzimidazolyliminoacetic acid N,N-diethylethanamine salt, was tested against C. elegans eggs. The MIC90 was found to be 400 μg/ml, and although the derivative was not tested against H. contortus eggs, this finding further suggests that C. elegans eggs have an exceptionally low degree of benzimidazole sensitivity.

Airaj Fasiuddin and William C. Campbell "Haemonchus contortus (Nematoda: Trichostrongylidae) Is Much More Sensitive than Caenorhabditis elegans (Nematoda: Rhabditidae) to the Ovicidal Action of Thiabendazole," Journal of Parasitology 86(3), 629-630, (1 June 2000). https://doi.org/10.1645/0022-3395(2000)086[0629:HCNTIM]2.0.CO;2
Published: 1 June 2000
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