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1 February 2001 TREATMENT WITH AGMATINE INHIBITS CRYPTOSPORIDIUM PARVUM INFECTION IN INFANT MICE
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Abstract

Cryptosporidium parvum is an intracellular protozoan parasite that causes enteric infection and diarrhea in a wide range of mammalian hosts, including humans and economically important livestock species. There are no effective vaccines or drug treatments available for cryptosporidiosis. Cryptosporidium parvum utilizes a unique metabolic pathway for the synthesis of polyamines, forming agmatine as an intermediary metabolite. We treated infant mice with oral doses of agmatine for 2 days before, the day of, and 5 days following experimental infection with C. parvum. Mice treated with agmatine were significantly less infected with C. parvum than were control mice receiving phosphate-buffered saline. Mice treated with agmatine only on the day of experimental infection with C. parvum were also significantly less infected than were control mice. These data suggest that exogenous agmatine alters the metabolism of C. parvum sufficient to interfere with its ability to colonize the mammalian intestine.

Danielle Moore, W. Ray Waters, Michael J. Wannemuehler, and James A. Harp "TREATMENT WITH AGMATINE INHIBITS CRYPTOSPORIDIUM PARVUM INFECTION IN INFANT MICE," Journal of Parasitology 87(1), 211-213, (1 February 2001). https://doi.org/10.1645/0022-3395(2001)087[0211:TWAICP]2.0.CO;2
Received: 20 March 2000; Accepted: 1 May 2000; Published: 1 February 2001
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