Clotrimazole, Ketoconazole, and Clodinafop-propargyl as Potent Growth Inhibitors of Equine Babesia Parasites During In Vitro Culture

Sabine Bork; Naoaki Yokoyama; Tomohide Matsuo; Florencia G. Claveria; Kozo Fujisaki; Ikuo Igarashi

doi:10.1645/0022-3395(2003)089[0604:CKACAP]2.0.CO;2

How to translate text using browser tools

1 June 2003 Clotrimazole, Ketoconazole, and Clodinafop-propargyl as Potent Growth Inhibitors of Equine Babesia Parasites During In Vitro Culture

Sabine Bork, Naoaki Yokoyama, Tomohide Matsuo, Florencia G. Claveria, Kozo Fujisaki, Ikuo Igarashi

Author Affiliations +

J. of Parasitology, 89(3):604-606 (2003). https://doi.org/10.1645/0022-3395(2003)089[0604:CKACAP]2.0.CO;2

Abstract

The antifungal agents clotrimazole (CLT) and ketoconazole (KC) and the herbicide clodinafop-propargyl (CP) inhibit growth of Plasmodium sp., Toxoplasma sp., and Trypanosoma sp. In the present study, we evaluated these drugs against the in vitro growth of the equine protozoan parasites Babesia equi and B. caballi. Clotrimazole (IC₅₀: 2 and 17 μM), KC (IC₅₀: 6 and 22 μM), and CP (IC₅₀: 450 and 354 μM) were effective growth inhibitors. Interestingly, intraerythrocytic KC-treated Babesia sp. were observed to be in immediate contact with the plasma fraction of the blood in electron microscopy. These results demonstrate the babesiacidial activities of these compounds and suggest their chemotherapeutic potential for the treatment of equine babesioses.

Citation Download Citation

Sabine Bork, Naoaki Yokoyama, Tomohide Matsuo, Florencia G. Claveria, Kozo Fujisaki, and Ikuo Igarashi "Clotrimazole, Ketoconazole, and Clodinafop-propargyl as Potent Growth Inhibitors of Equine Babesia Parasites During In Vitro Culture," Journal of Parasitology 89(3), 604-606, (1 June 2003). https://doi.org/10.1645/0022-3395(2003)089[0604:CKACAP]2.0.CO;2

Published: 1 June 2003

KEYWORDS/PHRASES

PUBLICATION TITLE:

COLLECTION:

PUBLICATION YEARS