The role of signal transduction mechanisms with regard to the host cell invasion mechanics used by apicomplexans appears to have been overlooked; indeed, it is obvious that a signal must be transduced from the surface of an invading parasite to an intracellular location within it once the parasite makes contact with a host cell for the invasion process to be initiated. Data outlined in this communication show strong evidence for the role of tyrosine phosphorylation in the molecular mechanics and control of invasion of host cells when set within the context of the available literature, as detailed in this study.