Thirty-three splenectomized Aotus lemurinus griseimembra monkeys with no previous experience with malaria were infected with the Vietnam Palo Alto strain of Plasmodium vivax. The median maximum parasite count was 280,000/μl. Nine splenectomized monkeys with previous infection with Plasmodium falciparum had median maximum parasite counts of 120,000/μl. Splenectomized Aotus nancymai monkeys supported infections at a lower level. Transmission via the bites of Anopheles dirus mosquitoes was obtained in a splenectomized A. lemurinus griseimembra, with a prepatent period of 31 days. It is estimated that between 1.5 × 108 and 1.6 × 109 parasites can be removed from an infected animal for molecular or diagnostic antigenic studies.
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1 April 2005
Observations on the Vietnam Palo Alto Strain of Plasmodium vivax in Two Species of Aotus Monkeys
William E. Collins,
JoAnn S. Sullivan,
G. Gale Galland,
Allison Williams,
Douglas Nace,
Tyrone Williams*,
John W. Barnwell
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