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1 August 2005 HOST GLUCOSE METABOLISM MEDIATES T4 AND IL-7 ACTION ON SCHISTOSOMA MANSONI DEVELOPMENT
Pasquine Saule, Jérôme Vicogne, Myriam Delacre, Laurence Macia, Anne Tailleux, Colette Dissous, Claude Auriault, Isabelle Wolowczuk
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Abstract

Interleukin (IL-)7 and thyroxin (T4) favor Schistosoma mansoni development. Their effect is similar, rather than identical; moreover, cotreatment acts synergistically on parasites. This questioned a common mediator to their action, which we hypothesized was host glucose metabolism. Infection with S. mansoni resulted in an early peak in glycemia immediately followed by a peak of insulinemia (D7-21). In IL-7 T4 cotreated infected animals, the peak of insulin was abrogated. We further assessed the consequences of experimentally induced glucose- or insulin-level variations on parasite development. Insulin treatment from day 14 to day 21 post-infection (PI) led to increased worm burden and parasite size, thus mimicking the effect of T4 on schistosome development. Interestingly, insulin treatment did not modify glycemia yet abrogated the hyperinsulinemia, normally occurring during infection. Finally, these treatments were associated with an alteration of the expression of parasite genes involved in glucose uptake. These experiments characterize the elaborate links between parasite and host metabolism and their reciprocal influences.

Pasquine Saule, Jérôme Vicogne, Myriam Delacre, Laurence Macia, Anne Tailleux, Colette Dissous, Claude Auriault, and Isabelle Wolowczuk "HOST GLUCOSE METABOLISM MEDIATES T4 AND IL-7 ACTION ON SCHISTOSOMA MANSONI DEVELOPMENT," Journal of Parasitology 91(4), 737-744, (1 August 2005). https://doi.org/10.1645/GE-3402.1
Received: 1 March 2004; Accepted: 1 October 2004; Published: 1 August 2005
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