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1 February 2013 Efficacy of Ivermectin Versus Dual Infections of Haemonchus contortus and Heligmosomoides polygyrus in the Mouse
D. A. Ostlind, W. G. Mickle, S. Smith, D. V. Ewanciw, S. Cifelli
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Abstract

This report describes a novel assay for the detection of gastrointestinal anthelmintics using mice infected with Haemonchus contortus and adapted to the 1 animal/test group protocol. Mice infected with both H. contortus and Heligmosomoides polygyrus were fed ivermectin-medicated diets for 6 days. A dietary level of 0.09375 ppm was 98.1% effective against the 0- to 6-day-old abomasal stomach worm of sheep, whereas a level of 0.75 ppm reduced the 3- to 9-day-old H. polygyrus worm burden by 94.0%. H. contortus was approximately 8-fold more sensitive to ivermectin than was H. polygyrus in this model. The sensitivity of this assay rivals that of the gerbil-Trichostrongylus colubriformis model while utilizing a more economical host.

D. A. Ostlind, W. G. Mickle, S. Smith, D. V. Ewanciw, and S. Cifelli "Efficacy of Ivermectin Versus Dual Infections of Haemonchus contortus and Heligmosomoides polygyrus in the Mouse," Journal of Parasitology 99(1), 168-169, (1 February 2013). https://doi.org/10.1645/12-22.1
Published: 1 February 2013
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