We investigated the efficacy, fate, and potential for direct effects on salmonids of 4 common mosquito larvicides (Mosquito Dunks® and Bits® (AI: Bacillis thuringiensis var. israelensis, [Bti]), VectoLex® WSP (AI: Bacillus sphaericus [Bs], VectoLex CG [AI: Bs], and Altosid® Briquets [AI: s-methoprene]) in Seattle, WA, during 3 summers. During efficacy trials in 2006, all treatments resulted in a rapid reduction in number of mosquito pupae (Mosquito Dunks and Bits and VectoLex WSP) or emergence success (Altosid Briquets). VectoLex CG was chosen for city-wide application in 2007 and 2008. The average counts of pupae within round-top basins remained significantly below the control average for 11 wk in 2007, whereas efficacy in grated-top basins was short-lived. In 2008 the average counts of pupae within grated-top basins remained significantly below the control average for 10 wk. Altosid XR was also effective in reducing adult emergence within grated basins in 2008. In 2007 and 2008, frequent precipitation events made the evaluation of efficacy difficult due to reductions in pupae across control and treated basins. Four separate analyses of VectoLex products revealed that the product was a combination of Bs and Bti. Both Bs and Bti were detected in 3 urban creeks connected to treated basins in 2007 and 2008. Laboratory toxicity test results suggest that concentrations of Bs and Bti detected in each of the watersheds pose little direct hazard to juvenile salmonids.