The dissorophid genus Conjunctio (Temnospondyli) is poorly characterized, known only from two incomplete specimens from the upper El Cobre Canyon Formation (lower Permian), Cutler Group, New Mexico, U.S.A. Nonetheless, the taxon's conserved morphology and stratigraphic occurrence near the Carboniferous–Permian boundary (ca. 299 million years ago) make it an important datum to resolve the early diversification of dissorophids. We report the first occurrence of Conjunctio cf. C. multidens in the adjacent undivided Cutler Formation of San Miguel County, Colorado, which also represents only the second dissorophid from southwestern Colorado's historic Placerville assemblage. The new specimen highlights the plesiomorphic anatomy of Conjunctio, with newly described mandibular and postcranial data, and provides further evidence for a relationship to the Eucacopinae. We performed a phylogenetic analysis of 34 temnospondyl taxa by modifying a previously published matrix of 102 craniodental and postcranial characters, scoring Conjunctio at the specimen-level, and found a monophyletic Conjunctio at the base of Eucacopinae. The clade also included the earliest Permian Reiszerpeton and Scapanops in relatively basal positions, and an unresolved polytomy among the later Permian Cacops, Kamacops, Zygosaurus, and Anakamacops. Geographically, the discovery of Conjunctio among the Placerville assemblage is consistent with a broader southwestern U.S. Wolfcampian fauna, correlative to that of the upper El Cobre Canyon Formation in northern New Mexico, and may underscore previously proposed regional provincialism among early Permian tetrapod assemblages.