Attempts to transfer sarcoptic mange from a red fox (Vulpes vulpes), four coyotes (Canis latrans), and a wolf (Canis lupus) to dogs (Canis familiaris) and apparent coyote-dog hybrids were unsuccessful. One coyote died of sarcoptic mange of red fox origin and two coyotes died of sarcoptic mange of coyote origin. Four suspected (i.e., mites were not demonstrated) human cases, all transitory in nature, resulted from handling infested coyotes.