Serologic evidence of contagious ecthyma (CE) was found in domestic sheep (Ovis aries), domestic goats (Capra hircus), Dall sheep (Ovis dalli), and muskox (Ovibos moschatus) in Alaska. A moose (Alces alces) calf and a caribou (Rangifer tarandus) fawn were susceptible to experimental infection and both developed antibody titers as a result. CE virus was isolated from lesions of Dall sheep which were involved in a natural outbreak of the disease.