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1 July 1986 XYLAZINE HYDROCHLORIDE–KETAMINE HYDROCHLORIDE IMMOBILIZATION OF WOLVES AND ITS ANTAGONISM BY TOLAZOLINE HYDROCHLORIDE
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Abstract

Fourteen wolves (Canis lupus L.) were singularly or repeatedly immobilized with 30 mg xylazine hydrochloride (HC1) and 400 mg ketamine HCl. Mean induction time was 5.3 ± 4.6 min (mean ± SD). Administration of 8.0 mg/kg tolazoline HCl as an antagonist significantly reduced immobilization times from 148.0 ± 52.7 to 47.9 ± 8.9 min (F = 63.69, df = 1,17, P < 0.05). The average times from injection to ambulation for 2.0, 4.0, and 8.0 mg/kg tolazoline HCl were 35.2 ± 31.8, 18.5 ± 11.7, and 10.2 ± 9.1 min. Tolazoline HCl increased heart rates significantly (P < 0.001) from 75 ± 14 to 120 ± 23 beats/min, reversing a xylazine HCl-induced bradycardia. Respiratory rates also increased significantly (P < 0.01) after tolazoline HCl injection from 19 ± 7 to 28 ± 8 breaths/min. Immobilization resulted in an initial hypertension which was normalized after tolazoline HCl administration. One female wolf had a single sinoatrial block within 1 min of receiving tolazoline HCl. Tolazoline HCl appears to be an effective antagonist for xylazine HCl–ketamine HCl immobilization of wolves.

Kreeger, Seal, and Faggella: XYLAZINE HYDROCHLORIDE–KETAMINE HYDROCHLORIDE IMMOBILIZATION OF WOLVES AND ITS ANTAGONISM BY TOLAZOLINE HYDROCHLORIDE
Terry J. Kreeger, Ulysses S. Seal, and Alicia M. Faggella "XYLAZINE HYDROCHLORIDE–KETAMINE HYDROCHLORIDE IMMOBILIZATION OF WOLVES AND ITS ANTAGONISM BY TOLAZOLINE HYDROCHLORIDE," Journal of Wildlife Diseases 22(3), 397-402, (1 July 1986). https://doi.org/10.7589/0090-3558-22.3.397
Received: 1 October 1985; Published: 1 July 1986
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