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1 October 1994 COMPARATIVE LEUKOTOXICITIES OF PASTEURELLA HAEMOLYTICA ISOLATES FROM DOMESTIC SHEEP AND FREE-RANGING BIGHORN SHEEP (OVIS CANADENSIS)
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Abstract

Twenty-eight isolates of Pasteurella haemolytica from domestic sheep (n = 14 isolates) and bighorn sheep (n = 14 isolates) were evaluated for leucotoxicity against peripheral blood neutrophils of bighorn sheep by adding bacterial culture supernatants to bighorn sheep neutrophils in vitro. Leukotoxic isolates of P. haemolytica, defined as causing >50% neutrophil death as measured by release of lactate dehydrogenase into culture supernatants, were identified from eight of 14 domestic sheep isolates and from 0 of 14 bighorn sheep isolates. The in vitro assay of isolates of P. haemolytica may provide a valid predictive measure of strain virulence of P. haemolytica, and of potential pneumonic episodes in bighorn sheep populations.

Sweeney, Silflow, and Foreyt: COMPARATIVE LEUKOTOXICITIES OF PASTEURELLA HAEMOLYTICA ISOLATES FROM DOMESTIC SHEEP AND FREE-RANGING BIGHORN SHEEP (OVIS CANADENSIS)
Steven J. Sweeney, Ronald M. Silflow, and William J. Foreyt "COMPARATIVE LEUKOTOXICITIES OF PASTEURELLA HAEMOLYTICA ISOLATES FROM DOMESTIC SHEEP AND FREE-RANGING BIGHORN SHEEP (OVIS CANADENSIS)," Journal of Wildlife Diseases 30(4), 523-528, (1 October 1994). https://doi.org/10.7589/0090-3558-30.4.523
Received: 29 October 1993; Published: 1 October 1994
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