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1 January 1999 EXPERIMENTAL NARTHECIUM OSSIFRAGUM NEPHROTOXICITY IN CERVIDS FROM NORWAY
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Abstract

One moose (Alces alces), two red deer (Cervus elaphus), two reindeer (Rangifer tarandus) and two fallow deer (Dama dama) were dosed intraruminally with an aqueous extract made from 30 g of bog asphodel (Narthecium ossifragum) (wet weight) per kg live weight. The moose and one of the two reindeer were mildly depressed and had reduced appetite 3 to 7 days and 1 to 4 days after dosing, respectively. The serum creatinine and urea concentrations increased markedly in the moose and red deer, and moderately in the reindeer. No increase in serum creatinine and urea was observed in the fallow deer. Histopathological examination of the kidneys of the animals, killed 8 to 10 days after dosing, revealed tubular epithelial cell degeneration, necrosis, and regeneration in the moose, red deer and reindeer. The renal lesions were severe in the moose, moderate in the red deer and mild in the reindeer. No histopathological lesions were seen in the kidneys of the fallow deer.

Flåøyen, Handeland, Stuve, Ryeng, and Refsum: EXPERIMENTAL NARTHECIUM OSSIFRAGUM NEPHROTOXICITY IN CERVIDS FROM NORWAY
Arne Flåøyen, Kjell Handeland, Gudbrand Stuve, Kathrine A. Ryeng, and Thorbjørn Refsum "EXPERIMENTAL NARTHECIUM OSSIFRAGUM NEPHROTOXICITY IN CERVIDS FROM NORWAY," Journal of Wildlife Diseases 35(1), 24-30, (1 January 1999). https://doi.org/10.7589/0090-3558-35.1.24
Received: 26 March 1998; Published: 1 January 1999
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