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1 October 2002 CROSS-PROTECTION BETWEEN EPIZOOTIC HEMORRHAGIC DISEASE VIRUS SEROTYPES 1 AND 2 IN WHITE-TAILED DEER
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Abstract

Viruses in the epizootic hemorrhagic disease (EHD) serogroup are the most frequent cause of hemorrhagic disease in the southeastern United States, but nothing is known about cross-protection between the two EHD serotypes (EHDV-1 and EHDV-2) present in this region. We experimentally tested whether deer surviving EHDV-2 infection would be protected against subsequent infection with EHDV-1, and used field data to examine the possibility of reciprocal cross-protection. Eleven white-tailed deer fawns (Odocoileus virginianus) were experimentally infected with EHDV-2 and later challenged with EHDV-1. Two EHDV-2-naïve fawns also were infected with EHDV-1. Deer were monitored via physical examination, complete blood counts, clotting profiles, viral isolation, and serology, and each animal was assigned a quantitative clinical disease severity score based on presence of certain physical and clinical parameters. Infection of naïve controls with EHDV-1 caused severe clinical disease and death of both fawns, whereas deer previously infected with EHDV-2 exhibited no or minimal signs of disease. Thus, infection with EHDV-2 conferred protection against disease caused by subsequent EHDV-1 infection. Although prior EHDV-2 exposure protected deer from severe clinical disease, it did not prevent infection nor viremia indicating they could still act as virus amplifying hosts. These experimental infections suggest that EHDV-1 and 2 may exist in a state of mutual permissiveness.

Gaydos, Davidson, Elvinger, Howerth, Murphy, and Stallknecht: CROSS-PROTECTION BETWEEN EPIZOOTIC HEMORRHAGIC DISEASE VIRUS SEROTYPES 1 AND 2 IN WHITE-TAILED DEER
Joseph K. Gaydos, William R. Davidson, François Elvinger, Elizabeth W. Howerth, Molly Murphy, and David E. Stallknecht "CROSS-PROTECTION BETWEEN EPIZOOTIC HEMORRHAGIC DISEASE VIRUS SEROTYPES 1 AND 2 IN WHITE-TAILED DEER," Journal of Wildlife Diseases 38(4), (1 October 2002). https://doi.org/10.7589/0090-3558-38.4.720
Received: 17 July 2001; Published: 1 October 2002
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