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1 October 2011 ACUTE PHASE PROTEIN RESPONSE IN THE CAPYBARA (HYDROCHOERUS HYDROCHAERIS)
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Abstract

We evaluated the acute phase protein response in capybaras (Hydrochoerus hydrochaeris). Three animal groups were used: 1) healthy animals (n=30), 2) a group in which experimental inflammation with turpentine was induced (n=6), and 3) a group affected with sarcoptic scabies (n=14) in which 10 animals were treated with ivermectin. Haptoglobin (Hp), acid-soluble glycoprotein (ASG) and albumin were analyzed in all animals. In those treated with turpentine, Hp reached its maximum value at 2 wk with a 2.7-fold increase, whereas ASG increased 1.75-fold and albumin decreased 0.87-fold 1 wk after the induction of inflammation. Capybaras affected with sarcoptic scabies presented increases in Hp and ASG of 4.98- and 3.18-fold, respectively, and a 0.87-fold decrease in albumin, compared with healthy animals. Haptoglobin and ASG can be considered as moderate, positive acute phase proteins in capybaras because they showed less than 10-fold increases after an inflammatory process and reached their peak concentrations 1 wk after the induction of inflammation. Conversely, albumin can be considered a negative acute phase protein in capybaras because it showed a reduction in concentration after inflammatory stimulus.

Luis Bernal, Mariane Feser, Silvia Martínez-Subiela, Juan D. García-Martínez, José J. Cerón, and Fernando Tecles "ACUTE PHASE PROTEIN RESPONSE IN THE CAPYBARA (HYDROCHOERUS HYDROCHAERIS)," Journal of Wildlife Diseases 47(4), 829-835, (1 October 2011). https://doi.org/10.7589/0090-3558-47.4.829
Received: 26 January 2011; Accepted: 1 July 2011; Published: 1 October 2011
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