Esophageal and pharyngeal obstruction are commonly reported in marine mammals, but asphyxiation from blowhole and nasal cavity obstruction has been reported only rarely: in two long-finned pilot whales (Globicephala melas), several harbor porpoises (Phocoena phocoena), and one common bottlenose dolphin (Tursiops truncatus). We describe two cases of blowhole obstruction and subsequent asphyxiation in bottlenose dolphins caused by eels. A whip eel (Bascanichthys scuticaris) was found obstructing the blowhole of a deceased dolphin from the Indian River Lagoon, Florida, US (2011) and a shrimp eel (Ophichthus gomesii) was found obstructing the blowhole of a deceased dolphin from Tampa Bay, Florida (2020). Normally, the respiratory and digestive tracts of cetaceans do not communicate. Consuming large or oddly shaped prey can result in laryngeal displacement and subsequent interaction between the two systems. It is likely the eels entered the oral cavity while the dolphins were consuming or playing with prey, and laryngeal displacement enabled the eels to slither into and become stuck in the nasal passage, causing asphyxiation. These novel findings underscore the importance of continued investigation into causes of mortality in stranded marine mammals and can contribute to the knowledge of feeding ecology in bottlenose dolphins. As changing environmental conditions contribute to shifts in prey availability and abundance, mortality due to prey-related asphyxiation could become more common in odontocetes.