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1 June 2000 EVALUATION OF A HUMAN IMMUNOMETRIC ASSAY FOR THE DETERMINATION OF THYROID-STIMULATING HORMONE IN NONHUMAN PRIMATES
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Abstract

Sera from nine species of clinically healthy nonhuman primates were assayed for T4 and thyroid-stimulating hormone (TSH) using human immunoassays (a fluorescence polarization immunoassay for T4, a microparticle enzyme immunoassay for TSH). The T4 levels ranged from 20 to 132 nmol/L ( ± SD = 62.8 ± 24.7 nmol/L). Levels of TSH were detected only in western lowland gorillas (Gorilla gorilla gorilla) and Sumatran orang-utans (Pongo pygmaeus abelii) (range, 0.4–10.8 mIU/L; detectable limit = 0.01 mIU/L). The results suggest that the antibodies used in the commercial TSH immunoassay assessed in this study cross-react with gorilla and orang-utan TSH but not with TSH of primates of the genera Macaca, Papio, Erythrocebus, Ateles, Leontopithecus, and Lemur.

Stéphane Lair, Graham J. Crawshaw, Kay G. Mehren, and Maria A. Perrone "EVALUATION OF A HUMAN IMMUNOMETRIC ASSAY FOR THE DETERMINATION OF THYROID-STIMULATING HORMONE IN NONHUMAN PRIMATES," Journal of Zoo and Wildlife Medicine 31(2), 267-268, (1 June 2000). https://doi.org/10.1638/1042-7260(2000)031[0267:EOAHIA]2.0.CO;2
Received: 15 February 2000; Published: 1 June 2000
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