This case report describes acariasis in captive, wild-caught, fat-tailed jirds (Pachyuromys duprasi). All animals within the cage (n = 4) were examined for pruritus and alopecia and subsequently found to be infested with the mite Pyroglyphis morganii. All life stages of the mite were identified on animals and within the nesting materials. Treatment, including repeated subcutaneous ivermectin administration and husbandry practice modifications, proved effective in eradicating the mites and in subsequent amelioration of clinical signs.