A 3-yr-old female corn snake, Pantherophis guttatus guttatus, was presented for clinical examination of anorexia and a cœlomic mass. Radiographs and ultrasound demonstrated a fluid-filled mass in the cardiac region. Surgical exploration revealed an approximately 1.2-cm, round, multilobulated, fluid-filled, nodular lesion firmly attached to the left atrial wall. Resection was attempted but proved unsuccessful and the animal was euthanized. Histopathological examination of the lesion revealed a large cystic structure associated with a cluster of variably sized, vascular channels lined by a one-cell-thick layer of endothelium, consistent with a cardiac hemangioma of the left atrium. This, to the best of the authors' knowledge, is the first report of such an occurrence in a snake.