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31 December 2013 INTRALESIONAL VINCRISTINE USE FOR TREATMENT OF SQUAMOUS CELL CARCINOMA IN A PUMA (PUMA CONCOLOR)
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Abstract

A 14-yr-old male puma (Puma concolor) was presented to the veterinary staff of the National Zoo in Malaysia for an auricular mass. Squamous cell carcinoma was diagnosed by histologic examination of a biopsy. Systemic administration of chemotherapy using vincristine (0.5 mg/m2 i.v. q. 7 days for six treatments) and prednisolone (2 mg/kg i.m. q. 72 hr × 7 days) caused side effects of vomiting, weight loss, and alopecia and did not improve the size or appearance of the tumor. Intralesional vincristine injections (0.2 mg q. 7 days for two treatments) and prednisolone (2 mg/kg i.m. q. 72 hr × 15 days) were administered, resulting in complete tumor regression after 14 days of treatment.

American Association of Zoo Veterinarians
Blanca Juarez Sandoval, Azlan Che' Amat, Jasni Sabri, and Mat Naim Ramli "INTRALESIONAL VINCRISTINE USE FOR TREATMENT OF SQUAMOUS CELL CARCINOMA IN A PUMA (PUMA CONCOLOR)," Journal of Zoo and Wildlife Medicine 44(4), 1059-1062, (31 December 2013). https://doi.org/10.1638/2011-0225R4.1
Received: 9 November 2011; Published: 31 December 2013
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