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1 June 2016 PHARMACOKINETIC EVALUATION OF A LONG-ACTING FENTANYL SOLUTION AFTER TRANSDERMAL ADMINISTRATION IN HELMETED GUINEAFOWL (NUMIDA MELEAGRIS)
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Abstract

The objective of this study was to investigate the pharmacokinetics of a long-acting fentanyl solution in helmeted guineafowl (Numida meleagris) after transdermal administration. Twenty-one guineafowl received a single administration of 5 mg/kg of fentanyl transdermal solution. No adverse effects on behavior were appreciated. Plasma fentanyl concentrations were determined by liquid chromatography–mass spectrometry analysis of protein-precipitated samples. Mean maximum plasma concentration was 228.8 ng/ml at 4 hr. The mean plasma terminal half-life was 33.2 hr. At 168 hr the mean plasma concentration was 1.3 ng/ml. A single topical dose of 5 mg/kg appears to be safe for use in this species and maintained plasma concentrations above those reported to be analgesic in dogs for at least 7 days.

Copyright 2016 by American Association of Zoo Veterinarians
Lynnette Waugh, Heather Knych, Gretchen Cole, and Jennifer D'Agostino "PHARMACOKINETIC EVALUATION OF A LONG-ACTING FENTANYL SOLUTION AFTER TRANSDERMAL ADMINISTRATION IN HELMETED GUINEAFOWL (NUMIDA MELEAGRIS)," Journal of Zoo and Wildlife Medicine 47(2), 468-473, (1 June 2016). https://doi.org/10.1638/2015-0220.1
Received: 17 September 2015; Published: 1 June 2016
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