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1 September 2016 COMBINATION THERAPY WITH FLUOXETINE AND ALPRAZOLAM TO CONTROL ANXIETY IN A HAND-REARED SNOW LEOPARD (UNCIA UNCIA)
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Abstract

A captive hand-reared adult male snow leopard (Uncia uncia) was treated for anxiety associated with taunting from visitors, the presence of large crowds, and introduction to a female for breeding. Behaviors included shaking, chewing on tail, panting, panicking, and bouncing off the viewing glass, pacing, and avoidance of the female. Combination therapy of oral fluoxetine and alprazolam were administered initially to minimize anxious behaviors while the fluoxetine achieved therapeutic levels. The alprazolam was tapered completely and was only used episodically on two occasions. Although a palatability issue with alprazolam initially prevented consistent dosing, anxious behavior was eliminated and successful breeding behavior was achieved for the first time. After 44 mo of therapy, there have been no anxious behaviors requiring additional medications, two additional breeding behaviors observed, and no evidence of adverse side effects with long-term use.

Copyright 2016 by American Association of Zoo Veterinarians
Holly J. Holman "COMBINATION THERAPY WITH FLUOXETINE AND ALPRAZOLAM TO CONTROL ANXIETY IN A HAND-REARED SNOW LEOPARD (UNCIA UNCIA)," Journal of Zoo and Wildlife Medicine 47(3), 900-902, (1 September 2016). https://doi.org/10.1638/2015-0146.1
Received: 24 June 2015; Published: 1 September 2016
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