PHARMACOKINETIC PARAMETERS OF CEFOVECIN SODIUM (CONVENIA) IN CAPTIVE TIGERS (PANTHERA TIGRIS)

Andrew C. Cushing; Edward C. Ramsay; James Steeil; Sherry Cox

doi:10.1638/2017-0083.1

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1 December 2017 PHARMACOKINETIC PARAMETERS OF CEFOVECIN SODIUM (CONVENIA) IN CAPTIVE TIGERS (PANTHERA TIGRIS)

Andrew C. Cushing, Edward C. Ramsay, James Steeil, Sherry Cox

Author Affiliations +

Andrew C. Cushing,^*,** Edward C. Ramsay,^** James Steeil,^** Sherry Cox^**

^*Correspondence should be directed to Dr. Cushing (acushin1@utk.edu).
^**From the Department of Small Animal Clinical Sciences (Cushing, Ramsay) and Biomedical and Diagnostic Services (Cox), College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, USA; and Wildlife Health Sciences, Smithsonian Institution National Zoological Park, 3001 Connecticut Avenue NW, Washington, D.C. 20013, USA (Steeil).

J. of Zoo and Wildlife Medicine, 48(4):1188-1192 (2017). https://doi.org/10.1638/2017-0083.1

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Abstract

A single 8 mg/kg dose of Cefovecin (Convenia®) was administered intramuscularly in the hindlimb of eight anesthetized captive tigers (Panthera tigris) and serial blood samples were collected over the next 56 days to determine pharmacokinetic characteristics. High-performance liquid chromatography was utilized to determine plasma levels, and demonstrated a mean terminal half-life of 227.8 ± 29.3 hr. Cefovecin, >1 μg/ml, was detected in plasma levels up to 56 days postinjection. Protein binding of tiger plasma for cefovecin was 98%. The long duration of therapeutic plasma concentrations and lack of adverse effects make cefovecin a useful antimicrobial drug for tigers.

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Andrew C. Cushing, Edward C. Ramsay, James Steeil, and Sherry Cox "PHARMACOKINETIC PARAMETERS OF CEFOVECIN SODIUM (CONVENIA) IN CAPTIVE TIGERS (PANTHERA TIGRIS)," Journal of Zoo and Wildlife Medicine 48(4), 1188-1192, (1 December 2017). https://doi.org/10.1638/2017-0083.1

Accepted: 1 August 2017; Published: 1 December 2017

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Journal of Zoo and Wildlife Medicine
Vol. 48 • No. 4
December 2017

KEYWORDS

Cefovecin

Convenia

Panthera tigris

pharmacokinetics

tiger

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Andrew C. Cushing, Edward C. Ramsay, James Steeil, Sherry Cox "PHARMACOKINETIC PARAMETERS OF CEFOVECIN SODIUM (CONVENIA) IN CAPTIVE TIGERS (PANTHERA TIGRIS)," Journal of Zoo and Wildlife Medicine, 48(4), 1188-1192, (1 December 2017)

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