Principal component analyses (PCA) and principal coordinate analyses (PCoA) suggest that Senegalia berlandieri (Benth.) Britton & Rose hybridizes with S. crassifolia (A. Gray) Britton & Rose, the resulting hybrid being S. × anisophylla (S. Watson) Britton & Rose. This uncommon hybrid is reported from the states of Coahuila, Durango, and San Luis Potosí, Mexico. In addition, PCA and PCoA suggest that S. berlandieri hybridizes with S. reniformis (Benth.) Britton & Rose. The resulting hybrid, S. berlandieri × reniformis, also is infrequent, being restricted to the state of Querétaro, Mexico. The morphological features of both probable F₁-hybrids are highly variable. The backcrosses to each respective parent were also examined. The hybrid between S. berlandieri and S. reniformis (Senegalia × zamudii Seigler, Ebinger, & Glass) is described.