A revision of the Andean species of Ocotea Aubl. occurring above 1000 m elevation with unisexual flowers and dense pubescence on the lower leaf surface or with erect pubescence or with domatia is presented. A key to and descriptions of the 35 recognized species are provided. Twenty-one species are described as new: O. antioquiensis van der Werff, O. argyrea van der Werff, O. otara van der Werff, O. santamartae van der Werff, and O. subparamicola van der Werff from Colombia; O. aquila van der Werff, O. euryphylla van der Werff, O. oreophila van der Werff, O. pastazensis van der Werff, and O. rufotomentella van der Werff from Ecuador; O. crassipedalis van der Werff, O. crinita van der Werff, O. kolera van der Werff, O. megistophylla van der Werff, O. palcazuensis van der Werff, O. papyracea van der Werff, O. satipensis van der Werff, and O. tarmensis van der Werff from Peru; O. adusta van der Werff and O. carchiensis van der Werff from Colombia and Ecuador; and O. recurvata van der Werff from Ecuador and Peru. Ocotea caesariata van der Werff is published as a replacement name for Pleurothyrium velutinum Meisn., incorrectly called O. calophylla Mez.