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1 October 2000 UVAI-induced Edema and Pyrimidine Dimers in Murine Skin
Ronald D. Ley, Anny Fourtanier
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The induction of edema and pyrimidine dimers in epidermal DNA was determined in the skin of SKH:HR1 mice exposed to graded doses of ultraviolet radiation AI (UVAI; 340–400 nm). Exposure to UVAI induced 1.6 ± 0.08 × 10−6 (mean ± standard error of mean) pyrimidine dimers per 108 Da of DNA per J/m2. Edema in irradiated animals was determined as an increase in skinfold thickness. A dose of 1.8 × 106 J/m2 of UVAI that resulted in a 50% increase in skinfold thickness (SFT50%) would have induced 1.0 × 105 dimers per basal cell genome. A similar increase in SFT induced by full spectrum solar ultraviolet radiation (290–400 nm) would accompany the induction of 11.0 × 105 pyrimidine dimers per basal cell genome. These results support a hypothesis that UVAI-induced pathological changes of the skin are mediated through the formation of nondimer photoproducts.

Ronald D. Ley and Anny Fourtanier "UVAI-induced Edema and Pyrimidine Dimers in Murine Skin," Photochemistry and Photobiology 72(4), 485-487, (1 October 2000).<0485:UIEAPD>2.0.CO;2
Received: 1 March 2000; Accepted: 1 July 2000; Published: 1 October 2000

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