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1 August 2001 Effect of Structural Modification on Photodynamic Activity of Hypocrellins
Jianghua Ma, Jingquan Zhao, Lijin Jiang
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Aluminum ion complexed 5,8-di-Br-hypocrellin B is a new water-soluble perylenequinonoid derivative with enhanced absorption over hypocrellin B (HB) in the phototherapeutic window (600–900 nm). Electron paramagnetic resonance and 9,10-diphenyl-anthracene bleaching methods were used to investigate the photosensitizing activity of [Al2(5,8-di-Br-HB)Cl4]n in the presence of oxygen. Singlet oxygen, superoxide anion radical and hydroxyl radical can be generated by [Al2(5,8-di-Br-HB)Cl4]n photosensitization. Singlet oxygen (1O2) is formed via energy transfer from triplet-state [Al2(5,8-di-Br-HB)Cl4]n to ground-state molecular oxygen. 1O2 participates in the generation of a portion of superoxide anion radical (O2·−). Besides superoxide anion radical (O2·−) may originate from the electron transfer between the triplet-state [Al2(5,8-di-Br-HB)Cl4]n and the ground-state molecular oxygen. ·OH is formed through the Fenton–Haber–Weiss reaction and the decomposition of DMPO–1O2 adduct. Compared with HB [Al2(5,8-di-Br-HB)Cl4]n primarily remains and enhances the generation efficiency of superoxide anion radical and hydroxyl radical but that of singlet oxygen decreases.

Jianghua Ma, Jingquan Zhao, and Lijin Jiang "Effect of Structural Modification on Photodynamic Activity of Hypocrellins," Photochemistry and Photobiology 74(2), 143-148, (1 August 2001).<0143:EOSMOP>2.0.CO;2
Received: 5 January 2001; Accepted: 1 May 2001; Published: 1 August 2001

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