Photosensitization of Hypomycin B—A Novel Perylenequinonoid Pigment with Only One Intramolecular Hydrogen Bond¶

Hong-Yu Zhang; Wei Liu; Wei-Zhong Liu; Jin-Lun Xie

doi:10.1562/0031-8655(2001)074<0191:POHBAN>2.0.CO;2

1 August 2001 Photosensitization of Hypomycin B—A Novel Perylenequinonoid Pigment with Only One Intramolecular Hydrogen Bond

Hong-Yu Zhang, Wei Liu, Wei-Zhong Liu, Jin-Lun Xie

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Photochemistry and Photobiology, 74(2):191-195 (2001). https://doi.org/10.1562/0031-8655(2001)074<0191:POHBAN>2.0.CO;2

Abstract

Electron spin resonance technique and spin-trapping methods were used to determine the photoproduction of ¹O₂ and O₂^·− by hypomycin B (HMB), a novel perylenequinonoid pigment (PQP) possessing only one hydroxyl group. It was found that the yields of ¹O₂ and O₂^·− for HMB were comparable to those for hypocrellin A, a typical natural PQP with good photosensitivity. In addition, the absorption and fluorescence spectra for HMB were investigated. The pKa values in the ground and excited states of HMB were determined to be 8.94 and 5.54, respectively. Thus, the photodynamic mechanisms of HMB may involve not only the photogeneration of ¹O₂ and O₂^·− but also the light-induced acidification. Consequently, HMB is proposed to be a good photodynamic therapeutic agent.

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Hong-Yu Zhang, Wei Liu, Wei-Zhong Liu, and Jin-Lun Xie "Photosensitization of Hypomycin B—A Novel Perylenequinonoid Pigment with Only One Intramolecular Hydrogen Bond," Photochemistry and Photobiology 74(2), 191-195, (1 August 2001). https://doi.org/10.1562/0031-8655(2001)074<0191:POHBAN>2.0.CO;2

Received: 8 January 2001; Accepted: 1 May 2001; Published: 1 August 2001

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