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1 March 2002 Spectroscopic Properties of Fluoroquinolone Antibiotics in Water–methanol and Water–acetonitrile Mixed Solvents
Hyoung-Ryun Park, Chu-Ha Oh, Hyeong-Chul Lee, Jin-Ki Lee, Kiyull Yang, Ki-Min Bark
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Abstract

The fluorescence properties of ofloxacin (OFL), norfloxacin (NOR) and flumequine (FLU) were studied in H2O–CH3OH and H2O–CH3CN mixed solvents because these solvents were thought to behave as a biological mimetic system. The emission spectra of OFL and NOR were very sensitive to the composition of the solvents. In the Lippert–Mataga analysis of the steady-state fluorescence data of OFL and NOR, clear reverse solvatochromism was exhibited in both mixed solvents. This observation can be explained by the twisted excited-state intramolecular charge transfer, which is accelerated by water. Theoretical treatments further support these results. The radiative and nonradiative rate constants were analyzed as a function of solvent dipolarity–polarizability (π*) and hydrogen-bond donor acidity (α). These results were well consistent with the suggested mechanism of the excited-state chemical process of OFL and NOR, which depended upon the solvent–solute interactions such as bulk dielectric effects and specific hydrogen-bonding interactions. However, the influence of dielectric effects was more significant. The solvent structures of H2O–CH3CN and the preferential solvation by water were also examined. The emission spectra of FLU do not exhibit any characteristic responses to the properties of the environment.

Hyoung-Ryun Park, Chu-Ha Oh, Hyeong-Chul Lee, Jin-Ki Lee, Kiyull Yang, and Ki-Min Bark "Spectroscopic Properties of Fluoroquinolone Antibiotics in Water–methanol and Water–acetonitrile Mixed Solvents," Photochemistry and Photobiology 75(3), 237-248, (1 March 2002). https://doi.org/10.1562/0031-8655(2002)075<0237:SPOFAI>2.0.CO;2
Received: 10 July 2001; Accepted: 1 December 2001; Published: 1 March 2002
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