Hesperetin Glucuronide, a Photoprotective Agent Arising from Flavonoid Metabolism in Human Skin Fibroblasts¶

Anna R. Proteggente; Sharmila Basu-Modak; Gunter Kuhnle; Matthew J. Gordon; Kuresh Youdim; Rex Tyrrell; Catherine A. Rice-Evans

doi:10.1562/0031-8655(2003)078<0256:HGAPAA>2.0.CO;2

1 September 2003 Hesperetin Glucuronide, a Photoprotective Agent Arising from Flavonoid Metabolism in Human Skin Fibroblasts

Anna R. Proteggente, Sharmila Basu-Modak, Gunter Kuhnle, Matthew J. Gordon, Kuresh Youdim, Rex Tyrrell, Catherine A. Rice-Evans

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Photochemistry and Photobiology, 78(3):256-261 (2003). https://doi.org/10.1562/0031-8655(2003)078<0256:HGAPAA>2.0.CO;2

Abstract

There is considerable interest in the biological properties of flavonoids in terms of their antioxidant and cytoprotective actions. The interaction of the flavanone hesperetin with human skin fibroblasts (FEK4) has revealed the potential for metabolism to hesperetin glucuronide and its subsequent extrusion. As a consequence of this observation, the effectiveness of hesperetin glucuronides, in comparison with that of the aglycone form, in protecting against UV-A radiation has been investigated. The results indicate that hesperetin glucuronides, but not hesperetin, protect against UV-A-induced necrotic cell death.

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Anna R. Proteggente, Sharmila Basu-Modak, Gunter Kuhnle, Matthew J. Gordon, Kuresh Youdim, Rex Tyrrell, and Catherine A. Rice-Evans "Hesperetin Glucuronide, a Photoprotective Agent Arising from Flavonoid Metabolism in Human Skin Fibroblasts," Photochemistry and Photobiology 78(3), 256-261, (1 September 2003). https://doi.org/10.1562/0031-8655(2003)078<0256:HGAPAA>2.0.CO;2

Received: 9 May 2003; Accepted: 1 June 2003; Published: 1 September 2003

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