1 July 2006 New Strategies of Photoprotection
Lien Verschooten, Sofie Claerhout, An Van Laethem, Patricia Agostinis, Marjan Garmyn
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Adequate photoprotection is essential to control UV-related disorders, including sunburn, photoaging and photocarcinogenisis. Sun avoidance, protection of skin with clothing, and sunscreens are presently the best way of photoprotection, assuming that they are used properly. However, new strategies, which are based on or make use of the endogenous protective response to UV light, may further improve currently used photoprotective means. The addition of repair enzymes and/or antioxidants has a positive effect on skin's recovery from UV-induced DNA-damage. Several botanical agents, mainly vitamins and polyphenols, have shown to influence signal transduction pathways leading to photoprotective effects. Also stimulation of endogenous UV-response pathways via irradiation with a low UV dose or via simulation of UV-induced DNA-damage results in photoprotective effects. Future research in this field and combination of different photoprotective strategies will hopefully lead to improved photoprotection.

Lien Verschooten, Sofie Claerhout, An Van Laethem, Patricia Agostinis, and Marjan Garmyn "New Strategies of Photoprotection," Photochemistry and Photobiology 82(4), 1016-1023, (1 July 2006). https://doi.org/10.1562/2006-04-27-IR-884.1
Received: 27 April 2006; Accepted: 1 May 2006; Published: 1 July 2006

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