We introduce the Politics and the Life Sciences Special Issue on Disgust and Political Attitudes discussing the importance of understanding state and trait disgust, the innovative and transparent process by which registered reports and preregistered studies were chosen and funded, and the manuscripts that make up this special issue. This essay concludes by discussing future research directions in disgust and political attitudes, as well as the benefits of a transparent review process that avoids the “file drawer problem” of unpublished null findings.