While there have always been those in the American public who mistrust science and scientists' views of the world, they have tended to be a minority of the larger public. Recent COVID-19 related events indicate that could be changing for some key groups. What might explain the present state of mistrust of science within an important component of the American public? In this study, we delve deeply into this question and examine what citizens today believe about science and technology and why, focusing on core theories of trust, risk concern, and political values and on the important role of science optimism and pessimism orientations. Using national public survey data, we examine the correlates of science optimism and pessimism and test the efficacy of this construct as drivers of biotechnology policy. We find that science optimism and pessimism are empirically useful constructs and that they are important predictors of biotechnology policy choices.