Fieldwork in the Ozark Mountains of the central United States by GRG over the last decade involving the American smoketree, Cotinus obovatus Raf. (Anacardiaceae), has resulted in the discovery of a previously unknown moth species belonging to the genus Cameraria (Lepidoptera: Gracillariidae). The larva of this species mines the leaf mesophyll of this tree, creating serpentine mines most visible from the upper (adaxial) surface of the leaf. The most closely related species to Cameraria cotinivora, n. sp. is Cameraria guttifinitella (Clemens), a common leafminer of poison ivy, Toxicodendron radicans (L.) Kuntze (Anacardiaceae). Illustrations of both species are provided as well as a COI analysis of their genetic relationship.