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1 April 2001 Double Lesions are Produced in DNA Oligomer by Ionizing Radiation and by Metal-Catalyzed H2O2 Reactions
Helen B. Patrzyc, Jean B. Dawidzik, Edwin E. Budzinski, Herbert Iijima, Harold C. Box
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Abstract

Patrzyc, H. B., Dawidzik, J. B., Budzinski, E. E., Iijima, H. and Box, H. C. Double Lesions are Produced in DNA Oligomer by Ionizing Radiation and by Metal-Catalyzed H2O2 Reactions.

It was demonstrated previously that double lesions are produced in DNA by ionizing radiation. These double lesions consist of adjacent nucleotides each bearing a modified base. The goal of the present investigation was to determine whether Fenton chemistry can generate the same kind of lesions. DNA oligomers were exposed to metal-catalyzed H2O2 reactions, and the products were characterized by chromatography and by mass spectrometry. Double lesions are produced by this treatment in which deoxyguanosine is oxidized to 8-oxo-7,8- dihydrodeoxyguanosine and an adjacent pyrimidine nucleoside is degraded to a formamido remnant.

Helen B. Patrzyc, Jean B. Dawidzik, Edwin E. Budzinski, Herbert Iijima, and Harold C. Box " Double Lesions are Produced in DNA Oligomer by Ionizing Radiation and by Metal-Catalyzed H2O2 Reactions," Radiation Research 155(4), 634-636, (1 April 2001). https://doi.org/10.1667/0033-7587(2001)155[0634:DLAPID]2.0.CO;2
Received: 15 May 2000; Accepted: 1 October 2000; Published: 1 April 2001
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