How to translate text using browser tools
1 November 2002 Multistage Models and the Incidence of Cancer in the Cohort of Atomic Bomb Survivors
Wolfgang F. Heidenreich, E. Georg Luebeck, William D. Hazelton, Herwig G. Paretzke, Suresh H. Moolgavkar
Author Affiliations +
Abstract

Heidenreich, W. F., Luebeck, E. G., Hazelton, W. D., Paretzke, H. G. and Moolgavkar, S. H. Multistage Models and the Incidence of Cancer in the Cohort of Atomic Bomb Survivors. Radiat. Res. 158, 607–614 (2002).

The analyses in this paper show that a number of biologically based models describe cancer incidence among the A-bomb survivors equally well. However, these different models can predict very different temporal patterns of risk after irradiation. No evidence was found to support the previous claim of Pierce and Mendelsohn that excess cancer risks for the solid tumors depend only upon attained age and not on age at exposure or time since exposure. Although the A-bomb survivor cohort is the largest epidemiological data set for the study of radiation and cancer, it is not large enough to discriminate among various possible carcinogenic mechanisms. Unfortunately for hypothesis generation, the data appear to be consistent with a number of different mechanistic interpretations of the role of radiation in carcinogenesis.

Wolfgang F. Heidenreich, E. Georg Luebeck, William D. Hazelton, Herwig G. Paretzke, and Suresh H. Moolgavkar "Multistage Models and the Incidence of Cancer in the Cohort of Atomic Bomb Survivors," Radiation Research 158(5), 607-614, (1 November 2002). https://doi.org/10.1667/0033-7587(2002)158[0607:MMATIO]2.0.CO;2
Received: 6 April 2001; Accepted: 1 June 2002; Published: 1 November 2002
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top