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1 February 2005 Sympathetic Hyperfunction Causes Increased Sensitivity of the Autonomic Nervous System to Whole-Body X Irradiation
Mutsumi Matsuu, Kazuko Shichijo, Yuji Ikeda, Masahiro Ito, Shinji Naito, Kumio Okaichi, Masahiro Nakashima, Toshiyuki Nakayama, Ichiro Sekine
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Abstract

Matsuu, M., Shichijo, K., Ikeda, Y., Ito, M., Naito, S., Okaichi, K., Nakashima, M., Nakayama, T. and Sekine, I. Sympathetic Hyperfunction Causes Increased Sensitivity of the Autonomic Nervous System to Whole-Body X Irradiation. Radiat. Res. 163, 137–143 (2005).

Although the etiology of radiation sickness is still unknown, disturbance of the autonomic nervous system is suggested to be a factor. This study was designed to compare the radiosensitivity of spontaneously hypertensive rats possessing sympathetic hyperfunction and control Wistar-Kyoto rats, and to analyze the effects of radiation on the autonomic nervous system in both strains. After a 7.5-Gy dose of whole-body X irradiation, the blood pressure decreased significantly at 8 h and 2 days in the spontaneously hypertensive rats, but not in the Wistar-Kyoto rats. Epinephrine levels in the adrenal gland of spontaneously hypertensive rats decreased at 4, 8 and 24 h, unlike the Wistar-Kyoto rats. Radiation evoked a stronger increase in norepinephrine in the jejunum and colon of spontaneously hypertensive rats than in Wistar-Kyoto rats. Acethylcholine levels in the jejunum of spontaneously hypertensive rats decreased, in contrast to the increase in Wistar-Kyoto rats within 24 h after irradiation. The survival rate of spontaneously hypertensive rats was lower than that of Wistar-Kyoto rats and weight loss, appetite loss and morphological changes in the jejunum were greater in spontaneously hypertensive rats than in Wistar-Kyoto rats after irradiation. These results indicated that X irradiation caused greater activities in autonomic nervous function and severe radiation injury in spontaneously hypertensive rats. Sympathetic hyperfunction may be associated with a higher sensitivity to radiation, including radiation injury and radiation sickness.

Mutsumi Matsuu, Kazuko Shichijo, Yuji Ikeda, Masahiro Ito, Shinji Naito, Kumio Okaichi, Masahiro Nakashima, Toshiyuki Nakayama, and Ichiro Sekine "Sympathetic Hyperfunction Causes Increased Sensitivity of the Autonomic Nervous System to Whole-Body X Irradiation," Radiation Research 163(2), 137-143, (1 February 2005). https://doi.org/10.1667/RR3294
Received: 27 June 2003; Accepted: 1 August 2004; Published: 1 February 2005
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