Translator Disclaimer
1 April 2006 Effects of Dietary Supplements on the Space Radiation-Induced Reduction in Total Antioxidant Status in CBA Mice
Author Affiliations +
Abstract

Guan, J., Stewart, J., Ware, J. H., Zhou, Z., Donahue, J. J. and Kennedy, A. R. Effects of Dietary Supplements on the Space Radiation-Induced Reduction in Total Antioxidant Status in CBA Mice. Radiat. Res. 165, 373–378 (2006).

In the present study, the total antioxidant status was used as a biomarker to evaluate oxidative stress induced by proton, HZE-particle and γ radiation in CBA mice. The results demonstrated that the plasma level of TAS was significantly decreased (P < 0.05) in CBA mice after exposure to a 50-cGy dose of radiation from HZE particles or a 3-Gy dose of radiation from protons or γ rays. Diet supplementation with Bowman-Birk Inhibitor Concentrate (BBIC), l-selenomethionine (l-SeM), or a combination of N-acetyl cysteine, sodium ascorbate, co-enzyme Q10 (CoQ10), α-lipoic acid, l-SeM and vitamin E succinate could partially or completely prevent the reduction in the plasma level of TAS in CBA mice exposed to proton or HZE-particle radiation. The selected antioxidant combination with or without CoQ10 has a comparable protective effect on the γ-radiation-induced drop in TAS in CBA mice. These results indicate that BBIC, l-SeM and the selected antioxidant combinations may serve as countermeasures for space radiation-induced adverse biological effects.

Jun Guan, Jelena Stewart, Jeffrey H. Ware, Zhaozong Zhou, Jeremiah J. Donahue, and Ann R. Kennedy "Effects of Dietary Supplements on the Space Radiation-Induced Reduction in Total Antioxidant Status in CBA Mice," Radiation Research 165(4), 373-378, (1 April 2006). https://doi.org/10.1667/RR3523.1
Received: 31 August 2005; Accepted: 1 December 2005; Published: 1 April 2006
JOURNAL ARTICLE
6 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top