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1 June 2009 Threshold-Type Dose Response for Induction of Neoplastic Transformation by 1 GeV/nucleon Iron Ions
E. Elmore, X-Y. Lao, R. Kapadia, J. L. Redpath
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Abstract

Elmore, E., Lao, X-Y., Kapadia, R. and Redpath, J. L. Threshold-Type Dose Response for Induction of Neoplastic Transformation by 1 GeV/nucleon Iron Ions. Radiat. Res. 171, 764ndash;770 (2009).

Neoplastic transformation of HeLa × skin fibroblast human hybrid cells by doses of 1 GeV/nucleon iron ions in the range 1 cGy to 1 Gy to exposed cultures has been examined. The data indicate a threshold-type dose–response curve with no increase in transformation frequency until doses above 20 cGy. At doses <10 cGy, not all exposed cells receive a direct traversal of an iron-ion track core, but all exposed cells receive up to several mGy of low-LET radiation associated with the δ-ray penumbra. It is proposed that the threshold-type response seen is a consequence of an adaptive response associated with the δ-ray exposure. For comparison purposes, the dose response for 137Cs γ rays over the same dose range was examined using the same experimental procedure. As we have shown previously, the dose response for 137Cs γ radiation was J-shaped. The iron ions were 1.5 to 1.7 times more biologically effective than the γ radiation over the dose range examined.

E. Elmore, X-Y. Lao, R. Kapadia, and J. L. Redpath "Threshold-Type Dose Response for Induction of Neoplastic Transformation by 1 GeV/nucleon Iron Ions," Radiation Research 171(6), 764-770, (1 June 2009). https://doi.org/10.1667/RR1673.1
Received: 18 November 2008; Accepted: 1 February 2009; Published: 1 June 2009
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