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10 May 2013 Prolongation of Life Span in the Accelerated Aging klotho Mouse Model, by Low-Dose-Rate Continuous γ Irradiation
Takaharu Nomura, Kazuo Sakai, Hiromitsu Ogata, Junji Magae
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Abstract

While lifespan studies provide basic information for estimating the risk of ionizing radiation, findings on the effect of low-dose/low-dose-rate irradiation on the lifespan of mammals are controversial. Here we evaluate the effect of continuous exposure to low-dose-rate γ radiation on the lifespan of mice with accelerated aging caused by mutation of the klotho gene. While control mice died within 80 days after birth, more than 10% of mice exposed continuously to 0.35 or 0.7 or mGy/h γ radiation from 40 days after birth survived for more than 80 days. Two of 50 mice survived for more than 100 days. Low-dose-rate irradiation significantly increased plasma calcium concentration in mutant mice, and concomitantly increased hepatic catalase activity. Although hepatic activity of superoxide dismutase in mutant mice decreased significantly compared to wild-type mice, continuous γ irradiation decreased the activity in mutant mice significantly. These results suggest that low-dose-rate ionizing radiation can prolong the lifespan of mice in certain settings.

Takaharu Nomura, Kazuo Sakai, Hiromitsu Ogata, and Junji Magae "Prolongation of Life Span in the Accelerated Aging klotho Mouse Model, by Low-Dose-Rate Continuous γ Irradiation," Radiation Research 179(6), 717-724, (10 May 2013). https://doi.org/10.1667/RR2977.1
Received: 23 February 2012; Accepted: 1 January 2013; Published: 10 May 2013
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