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10 May 2013 In Situ Expression of Heat-Shock Proteins and 3-Nitrotyrosine in Brains of Young Rats Exposed to a WiFi Signal In Utero and In Early Life
Saliha Aït-Aïssa, Florence Poulletier de Gannes, Murielle Taxile, Bernard Billaudel, Annabelle Hurtier, Emmanuelle Haro, Gilles Ruffié, Axel Athané, Bernard Veyret, Isabelle Lagroye
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Abstract

The bioeffects of exposure to Wireless High-Fidelity (WiFi) signals on the developing nervous systems of young rodents was investigated by assessing the in vivo and in situ expression levels of three stress markers: 3-Nitrotyrosine (3-NT), an oxidative stress marker and two heat-shock proteins (Hsp25 and Hsp70). These biomarkers were measured in the brains of young rats exposed to a 2450 MHz WiFi signal by immunohistochemistry. Pregnant rats were first exposed or sham exposed to WiFi from day 6 to day 21 of gestation. In addition three newborns per litter were further exposed up to 5 weeks old. Daily 2-h exposures were performed blind in a reverberation chamber and whole-body specific absorption rate levels were 0, 0.08, 0.4 and 4 W/kg. 3-NT and stress protein expression was assayed in different areas of the hippocampus and cortex. No significant difference was observed among exposed and sham-exposed groups. These results suggest that repeated exposure to WiFi during gestation and early life has no deleterious effects on the brains of young rats.

Saliha Aït-Aïssa, Florence Poulletier de Gannes, Murielle Taxile, Bernard Billaudel, Annabelle Hurtier, Emmanuelle Haro, Gilles Ruffié, Axel Athané, Bernard Veyret, and Isabelle Lagroye "In Situ Expression of Heat-Shock Proteins and 3-Nitrotyrosine in Brains of Young Rats Exposed to a WiFi Signal In Utero and In Early Life," Radiation Research 179(6), 707-716, (10 May 2013). https://doi.org/10.1667/RR2995.1
Received: 12 March 2012; Accepted: 1 December 2012; Published: 10 May 2013
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