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23 September 2013 The Murine Common Deletion: Mitochondrial DNA 3,860-bp Deletion after Irradiation
Steven B. Zhang, David Maguire, Mei Zhang, Zhenhuan Zhang, Amy Zhang, Liangjie Yin, Lurong Zhang, Luquiang Huang, Sadasivan Vidyasagar, Steven Swarts, Paul Okunieff
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Abstract

This study demonstrates that mice, similar to humans, have a common mitochondrial DNA deletion (3,860 bp) that encodes 5 transfer RNA genes and 5 polypeptide genes that is related to aging, tissue type and radiotoxicity. Our research indicates that the deletion ratio in the liver was significantly higher than in the brain and gut tissues of 8-month-old mice, as compared to 8-week-old mice. Our results also demonstrate that tissue type, oxidative metabolic capacity and radiosensitivity influence the 3,860-bp deletion level. Therefore, this 3,860-bp deletion content may serve as a biomarker of aging and oxidative damage in mice.

Steven B. Zhang, David Maguire, Mei Zhang, Zhenhuan Zhang, Amy Zhang, Liangjie Yin, Lurong Zhang, Luquiang Huang, Sadasivan Vidyasagar, Steven Swarts, and Paul Okunieff "The Murine Common Deletion: Mitochondrial DNA 3,860-bp Deletion after Irradiation," Radiation Research 180(4), 407-413, (23 September 2013). https://doi.org/10.1667/RR3373.1
Received: 5 April 2013; Accepted: 1 July 2013; Published: 23 September 2013
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