BioOne.org will be down briefly for maintenance on 17 December 2024 between 18:00-22:00 Pacific Time US. We apologize for any inconvenience.
How to translate text using browser tools
12 November 2013 Oral Interleukin 11 as a Countermeasure to Lethal Total-Body Irradiation in a Murine Model
Alexander F. Burnett, Prabath G. Biju, Huanli Lui, Martin Hauer-Jensen
Author Affiliations +
Abstract

Countermeasures against radiation are critically needed. Ideally, these measures would be easy to store, easy to administer and have minimal toxicity. We used oral delivery of interleukin 11 (IL11) in mice exposed to lethal doses of total-body irradiation (TBI). Animals were given IL11 by gavage at various daily doses beginning 24 h after TBI, which continued for 5 days. At a TBI of 9.0 Gy, mice treated with IL11 had a 70% survival at 30 days compared with control group survival of 25% (P = 0.035). At 10.0 Gy, treated animals had 50% survival at 30 days compared with no survivors in the control group. Treated animals had significant improvement in intestinal mucosal surface area and crypt survival. In addition bacterial translocation of coliform bacteria was significantly less in the treated animals. Systemic absorption of IL11 was low in treated animals and effects on the hematopoietic cells were not seen. Serum citrulline levels rebounded significantly faster after irradiation in the IL11 treated animals, indicating quicker recovery of small intestine health. These data suggest that IL11 given orally protects the intestinal mucosa from radiation damage and that this compound is beneficial as a mitigating agent even when started 24 h after radiation exposure.

Alexander F. Burnett, Prabath G. Biju, Huanli Lui, and Martin Hauer-Jensen "Oral Interleukin 11 as a Countermeasure to Lethal Total-Body Irradiation in a Murine Model," Radiation Research 180(6), 595-602, (12 November 2013). https://doi.org/10.1667/RR13330.1
Received: 3 February 2013; Accepted: 1 August 2013; Published: 12 November 2013
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top