How to translate text using browser tools
4 March 2015 The Triterpenoid RTA 408 is a Robust Mitigator of Hematopoietic Acute Radiation Syndrome in Mice
Devorah C. Goldman, Vitali Alexeev, Elizabeth Lash, Chandan Guha, Ulrich Rodeck, William H. Fleming
Author Affiliations +
Abstract

Bone marrow suppression due to exposure to ionizing radiation is a significant clinical problem associated with radiation therapy as well as with nonmedical radiation exposure. Currently, there are no small molecule agents available that can enhance hematopoietic regeneration after radiation exposure. Here, we report on the effective mitigation of acute hematopoietic radiation syndrome in mice by the synthetic triterpenoid, RTA 408. The administration of a brief course of RTA 408 treatment, beginning 24 h after lethal doses of radiation to bone marrow, significantly increased overall survival. Importantly, treatment with RTA 408 led to the full recovery of steady state hematopoiesis with normalization of the frequency of hematopoietic stem and progenitor cells. Moreover, hematopoietic stem cells from RTA 408-mitigated mice showed lineage-balanced, long-term, multilineage potential in serial transplantation assays, indicative of their normal self-renewal activity. The potency of RTA 408 in mitigating radiation-induced bone marrow suppression makes it an attractive candidate for potential clinical use in treating both therapy-related and unanticipated radiation exposure.

Devorah C. Goldman, Vitali Alexeev, Elizabeth Lash, Chandan Guha, Ulrich Rodeck, and William H. Fleming "The Triterpenoid RTA 408 is a Robust Mitigator of Hematopoietic Acute Radiation Syndrome in Mice," Radiation Research 183(3), 338-344, (4 March 2015). https://doi.org/10.1667/RR13900.1
Received: 8 September 2014; Accepted: 1 November 2014; Published: 4 March 2015
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top