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20 October 2015 A Comparison of Kinetic Photon Cell Survival Models
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Abstract

We report here on a qualitative and quantitative comparison of four kinetic photon cell survival models. The commonly used linear-quadratic model extended by a dose protraction factor, the lethal potentially lethal model, the repair misrepair model and the recently reported Giant LOop Binary LEsion (GLOBLE) model are discussed with respect to the proposed underlying biological mechanisms explaining the cellular response to radiation. Furthermore, with the use of eight benchmarks, the accuracy, reliability, resolution power and robustness of the models are assessed and compared. This work demonstrates that the linear-quadratic, lethal potentially lethal and GLOBLE models often perform equivalently and that the repair misrepair model appears to have some drawbacks regarding the end points under investigation.

©2015 by Radiation Research Society.
Lisa Herr, Thomas Friedrich, Marco Durante, and Michael Scholz "A Comparison of Kinetic Photon Cell Survival Models," Radiation Research 184(5), 494-508, (20 October 2015). https://doi.org/10.1667/RR13862.1
Received: 14 July 2014; Accepted: 1 September 2015; Published: 20 October 2015
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