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1 November 2015 Secondary Structure Alterations of Histones H2A and H2B in X-Irradiated Human Cancer Cells: Altered Histones Persist in Cells for at Least 24 Hours
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Abstract

We measured and compared the circular dichroism (CD) spectra and secondary structures of histone proteins H2A, H2B and their variants extracted from X-irradiated and unirradiated human HeLa cells. Compared to unirradiated cells, a relative increase in α-helix structure and decrease in other secondary structures was observed in X-irradiated cells. These structural alterations persisted for at least 24 h, which is substantially longer than the 2 h generally known to be required for DNA double-strand break repair.

©2015 by Radiation Research Society.
Yudai Izumi, Satoshi Yamamoto, Kentaro Fujii, and Akinari Yokoya "Secondary Structure Alterations of Histones H2A and H2B in X-Irradiated Human Cancer Cells: Altered Histones Persist in Cells for at Least 24 Hours," Radiation Research 184(5), 554-558, (1 November 2015). https://doi.org/10.1667/RR14071.1
Received: 2 March 2015; Accepted: 1 August 2015; Published: 1 November 2015
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